Application of stand-alone wind-solar-diesel-battery microgrid systems in remote islands has received increasing attention. In order to achieve stable， reliable， and economical operation of a stand-alone microgrid system， not only the full use of renewable energy must be considered， but also the constraints and influencing factors of energy storage systems should be combined. In view of the stand-alone wind-solar-diesel-battery microgrid system， the paper establishes the microgrid economic operation optimization model taking into account the depreciation cost， operation and maintenance cost， fuel cost， and environmental cost. The paper gives full consideration to the usage principles and influencing factors of lead-acid battery. Under the multi-objective of costs and lead-acid battery usage， the optimal scheme is obtained using the non-dominated sorting genetic algorithm（NSGA-Ⅱ）. The results show that the method presented can fully evaluate the economics of distributed generation and the life losses of lead-acid battery， meet the diverse needs of users and help determine the system economic operation scheme.