By studying the application basis of wide area protection， an intelligent protection system based on regional power network information is put forward to work in collaboration with the currently used main protection in strengthening the capability of power system relay protection and simplifying the backup protection. In the meantime， owing to the fact that wide area information is easily disturbed， lost and distorted， while not fully considered in current wide area protection principles， the decision-making and working mechanism of a new regional power network intelligent protection is proposed including the state correlation-based regional protection principle and the genetic algorithm-based fault identification principle. A fault mathematical model based on the genetic algorithm is developed. The simulation results have verified the validity and good fault-tolerance capability of the model proposed.