With the scale of electricity markets getting larger and larger， market participants，the electric contracts and wheeling are increasing， making the settlement problems in regional electricity markets exceptionally complicated. Based on the decoupling mechanism， new settlement methods， which are the hierarchical settlement method of decoupling the power grid settlement and power plan settlement， the method of decoupling the electric energy assessment and the operation assessment， and the method of decoupling the electric energy contract settlement and the electric energy deviation settlement， are proposed to effectively solve the ever growing complicated regional electricity market settlement problems. The proposed new settlement methods are now applied in the South China regional electricity market. The application results show that the new settlement methods can guarantee the transparency and fairness of market clearing and settlement and effectively solve the problems of coexistence of the plan-based electricity trade and inter-regional electricity trade， as well as power transmission from the west to the east.