Interaction is one of the important features of the smart grid. Existing studies on the interactive factors of the power system mainly focus on partial aspects such as source-grid coordination and interactive power consumption， to the neglect of overall thinking and systematic study of the grid operation and control in the complex environment of interaction between power supply， power grid and load. The concept and connotation ofsource-grid-load” interaction is proposed. The balance capability of power generation and consumption can be improved through coordinated interaction. Based on an analysis of the challenges in realizingsource-grid-load” interaction， six study fields of smart gridsource-grid-load” interactive operation and control framework are presented， i.e.， basic theory， characteristic analysis of complex interaction， modeling of complex interaction behavior， interactive capability identification， theory and method of safe operation analysis of interactive grid， flexible interactive coordinated control strategy and technology. An overview and outlook of each field are also given by referring to its demands.